P-TEFb Transcriptional Pause
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
The top hub genes MEPCE and HEXIM1 are the two core components of the 7SK snRNP complex that sequesters and inhibits P-TEFb (CDK9/CycT), thereby controlling RNA Pol II pause-release and transcriptional elongation. POLR2A (RNA Pol II largest subunit) is also present. SOCS1 (JAK-STAT suppressor), GADD45B (stress/NF-kB target), PLK2 (stress-induced kinase), IER5L (immediate early response), and RASD1 (RAS-related GTPase) round out a transcriptional stress-response program. The module is strongly upregulated in CD inflammation and suppressed by CD treatment, suggesting activation of P-TEFb-dependent transcriptional programs during CD-specific inflammatory stress.
Genes
Most correlated modules
- Mitochondrial Stress Adaptation · correlation 0.93
- Quiescent Progenitor State · correlation 0.88
- Splicing Regulation · correlation 0.78
- Immediate Early Response · correlation 0.52
- Replication Stress Response · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.