Splicing Regulation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
ARGLU1 is an arginine/glutamate-rich splicing coactivator that interacts with the spliceosome and mediates transcriptional coactivation; FUS is an RNA-binding protein and splicing regulator; SRSF7 is a serine/arginine-rich splicing factor (SR protein); RSRP1 is a serine-rich splicing-related protein. These four genes form a coherent RNA splicing/processing core. HOOK2 is a dynein adaptor involved in endosomal trafficking; AHI1 (Jouberin) is a ciliary transition zone protein with signaling roles; TLE4 is a Groucho-family transcriptional repressor; VEGFA is a hypoxia/VEGF pathway gene; TRIM73 and ANKRD36C are less characterized. ARHGEF38 is a Rho GEF. Upregulated in CD inflammation. The module is dominated by RNA splicing regulators with peripheral signaling genes, consistent with stress-induced alternative splicing in inflamed epithelium.
Genes
Most correlated modules
- Mitochondrial Stress Adaptation · correlation 0.85
- P-TEFb Transcriptional Pause · correlation 0.78
- Quiescent Progenitor State · correlation 0.61
- Replication Stress Response · correlation 0.56
- STAT3 Epithelial Remodeling · correlation 0.55
- Immediate Early Response · correlation 0.54
- Centrosome Biogenesis · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.