Mitochondrial Stress Adaptation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
YME1L1 is a mitochondrial inner-membrane AAA+ protease essential for mitochondrial quality control and OPA1 processing; COQ7 encodes a hydroxylase in coenzyme Q biosynthesis (mitochondrial electron transport). DDX3X is an RNA helicase involved in stress granule formation and translation regulation; INTS6 is an Integrator complex subunit for RNA Pol II regulation; IER5 is a stress-induced immediate-early gene; SLC38A2 is a stress-responsive amino acid transporter (SNAT2). JOSD1 is a deubiquitinase; PPP1R10 regulates PP1 phosphatase. Upregulated in CD inflammation. The module combines mitochondrial maintenance (YME1L1, COQ7) with stress-adaptive RNA/metabolic programs. In the context of the inflammatory neighborhood, this likely reflects mitochondrial stress adaptation in inflamed epithelium.
Genes
Most correlated modules
- P-TEFb Transcriptional Pause · correlation 0.93
- Splicing Regulation · correlation 0.85
- Quiescent Progenitor State · correlation 0.75
- Immediate Early Response · correlation 0.64
- STAT3 Epithelial Remodeling · correlation 0.50
- Replication Stress Response · correlation 0.43
- NF-κB Secondary Response · correlation 0.33
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.