Immediate Early Response
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
All hub genes (FOSB, JUN, IER2, IER3, BTG2, PPP1R15A, EGR1, NR4A1) are canonical immediate-early genes (IEGs) induced by stress, growth factors, and inflammatory signals. HES1 is a Notch/stress-responsive TF, ELF3 an epithelial TF co-induced with IEGs. High pct positive (84%) and uniform expression indicate a broadly active basal stress-response program. Decreased in UC inflammation but increased in CD and remission suggests context-dependent IEG regulation. Neighbor modules (M85, M27) are NF-κB inflammatory — M46 likely represents the upstream/parallel immediate-early arm of the same stress response.
Genes
Most correlated modules
- NF-κB Secondary Response · correlation 0.74
- EGFR-mediated Repair · correlation 0.68
- Mitochondrial Stress Adaptation · correlation 0.64
- Heat Shock Response · correlation 0.63
- Splicing Regulation · correlation 0.54
- P-TEFb Transcriptional Pause · correlation 0.52
- EGFR Wound Migration · correlation 0.50
- NF-κB Chemokine Response · correlation 0.44
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.