Epithelial Barrier Innate Immunity
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
MUC13 is a transmembrane mucin critical for epithelial barrier protection and is upregulated in colitis. INAVA (innate immunity activator) is a scaffold protein linking pattern recognition to NF-κB and barrier function. ANXA2 and ANXA11 are annexins involved in membrane repair and vesicle trafficking at the epithelial surface. ACTR3 (Arp3) and CAP1 drive actin polymerization for cytoskeletal remodeling. VASP links actin dynamics to cell-cell junctions. IL18 is an inflammasome-derived cytokine produced by colonocytes. SELENOS protects against ER stress. SDCBP2 (syntenin-2) regulates syndecan-mediated adhesion. The module is upregulated in inflammation and reflects epithelial barrier maintenance with innate immune activation.
Genes
Most correlated modules
- Epithelial Stress Repair · correlation 0.88
- S100 Cytoskeletal Stress · correlation 0.85
- Cytoskeletal Junction · correlation 0.79
- Hypoxia Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.