Cytoskeletal Junction
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SPTBN1 (spectrin beta-2, cortical cytoskeleton), CTNNA1 (alpha-catenin, actin-adherens junction linker), MYH9 (non-muscle myosin IIA, actomyosin contractility), CAST (calpastatin, calpain inhibitor regulating cytoskeletal remodeling), ACTR2 (ARP2, actin nucleation), DSC2 (desmocollin-2, desmosomal cadherin), and MTUS1 (microtubule-associated tumor suppressor) collectively define a cytoskeletal integrity and cell junction program. Mild inflammation association may reflect cytoskeletal remodeling during epithelial stress. No strong contamination signal.
Genes
Most correlated modules
- Protein Glycosylation · correlation 0.85
- Epithelial Cell Adhesion · correlation 0.85
- Mitochondrial Cristae Organization · correlation 0.82
- ER Stress UPR · correlation 0.80
- Epithelial Barrier Innate Immunity · correlation 0.79
- Hypoxia Response · correlation 0.78
- Glycolytic Barrier Stress · correlation 0.75
- Epithelial Stress Repair · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.