S100 Cytoskeletal Stress
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes CLTB (clathrin light chain B, endocytosis/vesicle trafficking), S100A16 (S100 calcium-binding protein, stress/inflammation), RHOC (Rho GTPase C, cytoskeletal/migration), CYSTM1 (cysteine-rich transmembrane module), CIB1 (calcium and integrin binding protein 1, integrin signaling), S100A11 (S100 calcium-binding protein, inflammation/cytoskeletal), TMEM54 (transmembrane protein 54), SH3BGRL3 (SH3 domain binding glutamate-rich protein, cytoskeletal). The module is dominated by S100 calcium-binding proteins (S100A16, S100A11), a Rho GTPase (RHOC), and cytoskeletal/membrane regulators. S100A11 and S100A16 are associated with epithelial stress responses and inflammation. RHOC drives cytoskeletal remodeling. The significant increase in UC inflammation (delta=0.215) and decrease in remission strongly supports an inflammatory/stress-activated cytoskeletal program. This module is a neighbor to M62 which also has S100 proteins and thymosin beta (TMSB4X), reinforcing a shared cytoskeletal/S100 program.
Genes
Most correlated modules
- Thymosin-S100 Cytoskeletal · correlation 0.92
- Metabolic Housekeeping · correlation 0.91
- Epithelial Stress Repair · correlation 0.89
- Mitochondrial Sulfur Detox · correlation 0.88
- Golgi Secretory Processing · correlation 0.87
- Epithelial Barrier Innate Immunity · correlation 0.85
- Mitochondrial Biogenesis · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.