Epithelial Stress Repair
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
KRT19 is a pan-epithelial keratin marking simple epithelium. SLPI is a secreted serine protease inhibitor with anti-inflammatory and barrier-protective roles in mucosal epithelium. S100P is a calcium-binding protein upregulated in epithelial stress and inflammation. FAM3C (ILEI) is a cytokine-like factor involved in epithelial plasticity. TSPAN1 is an epithelial tetraspanin. RHBDL2 is a rhomboid protease that sheds EGF-family ligands, relevant to epithelial repair. AGPAT2 is involved in lipid/phospholipid synthesis. MISP (mitotic spindle positioning) may reflect proliferative progenitor activity. Upregulated in UC inflammation, consistent with an epithelial stress/repair response.
Genes
Most correlated modules
- S100 Cytoskeletal Stress · correlation 0.89
- Epithelial Barrier Innate Immunity · correlation 0.88
- Glycolytic Barrier Stress · correlation 0.84
- Golgi Secretory Processing · correlation 0.84
- Thymosin-S100 Cytoskeletal · correlation 0.81
- Mature Colonocyte · correlation 0.81
- Cytoskeletal Junction · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.