DNA Replication Fork
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
MCM3, MCM4, MCM5, MCM6, MCM7 form the core MCM2-7 replicative helicase complex — the canonical S-phase licensing/elongation machinery. GINS2 is part of the CMG helicase. PCNA is the sliding clamp essential for DNA replication. DTL (CDT2) is a replication-coupled ubiquitin ligase. UHRF1 links replication to DNA methylation maintenance. MSH2 is a mismatch repair factor. RFC4 is a clamp loader subunit. RMI2 is a Holliday junction resolvase. DUT (dUTPase) prevents uracil incorporation. UNG (uracil-DNA glycosylase) repairs replication errors. NASP is a histone chaperone for S-phase. All genes are core/strong members. This is the tightest and most canonical DNA replication elongation module in the batch. Strongly decreased in inflammation (negative delta_inflammation_UC/CD), increased in remission — consistent with proliferative recovery. Neighbor context: the central S-phase replication hub, with M94 (initiation), M76 (lagging strand), and M25 (HR/chromatin) as complementary arms.
Genes
Most correlated modules
- DNA Repair S-phase · correlation 0.84
- Replication Initiation · correlation 0.83
- S-phase Progression · correlation 0.83
- Lagging Strand Synthesis · correlation 0.79
- DNA Replication/Repair · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.