DNA Replication/Repair
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes FANCD2, RAD51AP1, ESCO2, ORC6, CDCA5, PLK4, FBXO5, and E2F8 are all involved in DNA replication licensing, S-phase progression, and DNA damage response/repair. FANCD2 is a Fanconi anemia pathway DNA repair gene; RAD51AP1 promotes homologous recombination; ESCO2 is a cohesin acetyltransferase required for sister chromatid cohesion; ORC6 is part of the origin recognition complex; CDCA5 (sororin) stabilizes cohesin; PLK4 regulates centriole duplication; FBXO5 (Emi1) inhibits APC/C to allow S-phase entry; E2F8 is a transcriptional repressor of E2F targets in late S/G2. Together these genes define a DNA replication and repair program active in S-phase. The module is down in CD inflammation and up in UC remission, consistent with reduced proliferation during active inflammation. Neighbor context: this module sits alongside other cell cycle modules (M35, M81, M28) covering mitosis and kinetochore assembly, confirming a cell cycle neighborhood.
Genes
Most correlated modules
- S-phase Progression · correlation 0.92
- DNA Repair S-phase · correlation 0.87
- Lagging Strand Synthesis · correlation 0.83
- Mitotic Spindle · correlation 0.83
- Centrosome Biogenesis · correlation 0.81
- Replication Initiation · correlation 0.80
- S/G2 Transition · correlation 0.79
- Nuclear Architecture · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.