DNA Repair S-phase
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes BRCA1, BRCA2, BARD1 are canonical homologous recombination/DNA damage repair factors. ATAD2, EZH2, DNMT1, CHAF1A are chromatin remodeling and epigenetic regulators active in S-phase. HELLS is a chromatin remodeler required for DNA methylation. CLSPN, ATAD5, MCM10, TIMELESS are replication fork protection and S-phase checkpoint genes. NCAPD3 is a condensin II subunit. WDR76 and CEP78 are less central but associated with genome maintenance. The module is enriched for S-phase DNA replication fidelity, HR repair, and epigenetic maintenance — a DNA replication/repair chromatin program. Neighbor context: this batch is dominated by cell cycle sub-programs (M56, M34, M63, M76, M38, M94); M25 represents the S-phase chromatin/HR repair arm. Delta_remission_UC is positive, consistent with increased proliferation in remission. Concordant genes: BRCA1, BRCA2, BARD1, ATAD2, HELLS, CLSPN, ATAD5, DNMT1, CHAF1A, MCM10, TIMELESS, NCAPD3, EZH2.
Genes
Most correlated modules
- Replication Initiation · correlation 0.89
- DNA Replication/Repair · correlation 0.87
- S-phase Progression · correlation 0.85
- DNA Replication Fork · correlation 0.84
- Lagging Strand Synthesis · correlation 0.83
- Centrosome Biogenesis · correlation 0.74
- Replication Stress Response · correlation 0.69
- Mitotic Spindle · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.