Lagging Strand Synthesis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
LIG1 (DNA ligase I, Okazaki fragment ligation/S-phase), ASF1B (histone chaperone, S-phase chromatin assembly), RRM1/RRM2 (ribonucleotide reductase, dNTP synthesis), FEN1 (flap endonuclease, Okazaki fragment processing), CENPU (kinetochore), PRIM1 (DNA primase), DIAPH3 (formin, cytokinesis). RRM2 is a canonical S-phase marker. CTNNAL1 (alpha-catulin) is less clearly cell-cycle linked but may reflect cytoskeletal remodeling. This module represents DNA replication elongation and Okazaki fragment processing — a lagging strand synthesis program. Positive delta_remission_UC consistent with increased S-phase activity in remission. Neighbor context: closely related to M38 (MCM/PCNA elongation) and M94 (replication initiation), representing the lagging strand processing arm.
Genes
Most correlated modules
- S-phase Progression · correlation 0.87
- DNA Replication/Repair · correlation 0.83
- DNA Repair S-phase · correlation 0.83
- Replication Initiation · correlation 0.80
- DNA Replication Fork · correlation 0.79
- Mitotic Spindle · correlation 0.60
- Centrosome Biogenesis · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.