Replication Initiation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
CDC6 and CDC45 are essential replication initiation factors (pre-RC/CMG helicase loading). MCM8 is a replication helicase. FANCI is a Fanconi anemia DNA repair factor active at stalled replication forks. PKMYT1 is a G2/M checkpoint kinase (inhibits CDK1). BRIP1 (FANCJ) is a Fanconi anemia helicase/DNA repair factor. TCF19 is a cell cycle transcription factor. ZNF367 is associated with DNA replication. This module captures replication initiation and Fanconi anemia/replication stress response — an S-phase replication initiation program. Positive delta_remission_UC and negative delta_inflammation_CD suggest this proliferative program is suppressed during active CD inflammation. Neighbor context: complements M38 (MCM complex/elongation) and M25 (HR repair) as the replication initiation arm.
Genes
Most correlated modules
- DNA Repair S-phase · correlation 0.89
- S-phase Progression · correlation 0.85
- DNA Replication Fork · correlation 0.83
- DNA Replication/Repair · correlation 0.80
- Lagging Strand Synthesis · correlation 0.80
- Centrosome Biogenesis · correlation 0.63
- Replication Stress Response · correlation 0.53
- Mitotic Spindle · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.