Epithelial Wound Healing
Gene co-expression module in Microfold-like cells
| Category | Epithelial cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include EGFR ligands AREG and HBEGF (wound healing), MYC and WEE1/CDCA7 (cell cycle checkpoint/proliferation), NUPR1 and GDF15 (stress/damage response), RNF186 (IBD-associated E3 ligase), and KCNN4 (epithelial ion channel). Together these define an epithelial wound-healing and regenerative program driven by EGFR signaling. The disease association (decreased in CD inflammation, increased with UC treatment) supports a regenerative/repair response. Neighbor M11 shares the proliferative component; M10 adds the EGFR-driven repair dimension.
Genes
Most correlated modules
- Colonocyte Lipid Ion Transport · correlation 0.97
- Colonocyte Proliferative Recovery · correlation 0.93
- Mucosal Restitution Secretory · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.