Mucosal Restitution Secretory
Gene co-expression module in Microfold-like cells
| Category | secretory cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include TFF1 (trefoil factor 1, mucosal restitution and protection), SLPI (secretory leukocyte protease inhibitor, anti-inflammatory mucosal defense), SPINK1 (serine protease inhibitor Kazal type 1, mucosal protection), SERPINB5 (maspin, serine protease inhibitor), FABP2 (intestinal FABP, absorptive), NOX1 (NADPH oxidase 1, colonocyte ROS), SDC1 (syndecan-1, epithelial integrity), PDZK1IP1 (MAP17, brush border), and IDH2 (TCA cycle). TFF1, SLPI, SPINK1, SERPINB5 form a coherent mucosal protective/restitution secretory program. Increased significantly with CD treatment, consistent with mucosal healing. PXMP2 (peroxisomal) and LDHB are metabolic accessories.
Genes
Most correlated modules
- Colonocyte Proliferative Recovery · correlation 0.99
- Mitochondrial Assembly · correlation 0.97
- Colonocyte Lipid Ion Transport · correlation 0.96
- Interferon Antigen Processing · correlation 0.95
- Absorptive Colonocyte Identity · correlation 0.92
- Epithelial Wound Healing · correlation 0.91
- Epithelial Proliferation · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.