Colonocyte Proliferative Recovery
Gene co-expression module in Microfold-like cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include DUT (dUTPase, DNA replication fidelity), NASP (histone chaperone, S-phase), LBR and TMPO (nuclear lamina/envelope integrity), SMS (spermine synthase, polyamine biosynthesis supporting proliferation), ASPH (aspartyl hydroxylase), and FABP5 (lipid metabolism). The nuclear envelope and DNA replication genes (DUT, NASP, LBR, TMPO) suggest a proliferative or cell cycle-associated program. Polyamine synthesis (SMS) further supports cell growth. CXCL1 is a peripheral inflammatory gene. The module is decreased in CD inflammation and restored with CD treatment, consistent with recovery of a homeostatic proliferative program in colonocyte-like cells.
Genes
Most correlated modules
- Mucosal Restitution Secretory · correlation 0.99
- Interferon Antigen Processing · correlation 0.97
- Mitochondrial Assembly · correlation 0.97
- Colonocyte Lipid Ion Transport · correlation 0.96
- Colonocyte Metabolic Homeostasis · correlation 0.95
- Absorptive Colonocyte Identity · correlation 0.95
- Epithelial Wound Healing · correlation 0.93
- Epithelial Proliferation · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.