Colonocyte Lipid Ion Transport
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include EBPL (emopamil binding protein-like, sterol/cholesterol biosynthesis), ST6GAL1 (β-galactoside α-2,6-sialyltransferase, glycoprotein sialylation, colonocyte surface), CPT1A (carnitine palmitoyltransferase 1A, rate-limiting step of mitochondrial fatty acid oxidation), CFTR (cystic fibrosis transmembrane conductance regulator, Cl⁻/HCO₃⁻ ion channel, colonocyte function), MT1M and MT1E (metallothioneins, metal detoxification/stress), ADIRF (adipogenesis regulatory factor), ADH1C (alcohol dehydrogenase 1C, colonocyte xenobiotic metabolism), HMGCS2 (HMG-CoA synthase 2, ketogenesis and cholesterol synthesis), IMPDH2 (inosine monophosphate dehydrogenase 2, purine synthesis). CFTR, CPT1A, HMGCS2, ST6GAL1, ADH1C, EBPL collectively define colonocyte lipid/ion transport metabolic identity. Strongly decreased in UC inflammation and restored with CD treatment, indicating loss and recovery of colonocyte metabolic differentiation. Neighbor to M62 (absorptive colonocyte identity), supporting a complementary colonocyte lipid/ion metabolism program.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.97
- Epithelial Wound Healing · correlation 0.97
- Colonocyte Proliferative Recovery · correlation 0.96
- Colonocyte Metabolic Homeostasis · correlation 0.96
- Mucosal Restitution Secretory · correlation 0.96
- Intestinal Stem Cell · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.