NF-κB Inflammatory Activation
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CXCL3 (neutrophil chemokine), IRF1 (interferon regulatory factor), CEBPD (acute-phase transcription factor), HLA-DPB1 (MHC class II antigen presentation), and MDK (pro-inflammatory growth factor) define a strong NF-κB/IRF1-driven inflammatory activation program in macrophage-like cells. The module is significantly upregulated in both UC and CD inflammation and reduced in remission, consistent with active mucosal inflammation. IGHG3 may reflect ambient B cell RNA but does not override the dominant inflammatory signature.
Genes
Most correlated modules
- Colonocyte Differentiation · correlation 0.93
- NF-κB Inflammatory Response · correlation 0.90
- Absorptive Colonocyte Identity · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.