Absorptive Colonocyte Identity
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes SLC26A2 (sulfate/anion transporter, canonical colonocyte marker), CA1 and CA2 (carbonic anhydrases highly expressed in colonocytes for bicarbonate transport), FABP1 (intestinal fatty acid binding protein, absorptive cell marker), CES2 (carboxylesterase, colonocyte-enriched), HSD11B2 (11β-hydroxysteroid dehydrogenase, colonocyte), MGLL (monoglyceride lipase, lipid absorption), and QSOX1 (oxidoreductase) collectively define a mature absorptive colonocyte identity. S100A9 and HMGB2 are peripheral. The module is upregulated in UC inflammation (possibly reactive absorptive cells) and downregulated in CD inflammation. This is a classic absorptive colonocyte differentiation signature.
Genes
Most correlated modules
- Interferon Antigen Processing · correlation 0.96
- Colonocyte Metabolic Homeostasis · correlation 0.96
- Colonocyte Proliferative Recovery · correlation 0.95
- Mature Colonocyte Identity · correlation 0.94
- Epithelial Proliferation · correlation 0.94
- Mucosal Restitution Secretory · correlation 0.92
- NF-κB Inflammatory Activation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.