Colonocyte Differentiation
Gene co-expression module in Microfold-like cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
KLF4 is a master transcription factor for colonocyte terminal differentiation. SLC4A4 encodes a basolateral bicarbonate transporter essential for colonocyte ion homeostasis. ERBB3 mediates EGF-family signaling important for epithelial maintenance. LDLR is expressed in differentiating colonocytes for lipid uptake. MYB regulates epithelial proliferation-to-differentiation transition. NCL, ILF3, HNRNPD, DDX21, and IVNS1ABP are RNA-binding/processing proteins co-regulated during differentiation. SYNE2 anchors the nucleus during cell polarization. The module responds positively to CD treatment, consistent with restoration of differentiated colonocyte identity. This represents a colonocyte differentiation program.
Genes
Most correlated modules
- Intestinal Stem Cell · correlation 0.98
- Antigen Presentation Housekeeping · correlation 0.97
- Colonocyte Metabolic Homeostasis · correlation 0.96
- mRNA Splicing Processing · correlation 0.95
- NF-κB Inflammatory Activation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.