Metallothionein Response
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All 8 genes are metallothioneins (MT1X, MT1E, MT1F, MT1G, MT2A, MT1M, MT1H, MT1A) — small cysteine-rich proteins that bind heavy metals (zinc, copper) and protect against oxidative stress. The module is significantly downregulated with inflammation (delta_inflammation = -0.910, sig.) and restored with UC remission (delta_remission_UC = 1.108, sig.), consistent with metallothionein suppression during inflammatory stress and recovery during healing. Enriched in BEST4+ colonocytes. This is a tightly coherent, unambiguous metallothionein/metal stress response module.
Genes
Most correlated modules
- BEST4+ Colonocyte Identity · correlation 0.40
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.