SCUBA

MT2A — Metallothionein 2A

MT2A belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MT2A's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmunoproteasome IFN
Anti-viral
APRT, BATF, MT1X, NIT2, PSMB9, PSME1, PSME2, VAMP5View in SCUBA
CD8⁺ T cellsIFN-gamma Stress Response
Inflammation
COX5B, FABP5, MT1E, PHPT1, PSMB9, PSME2, SUB1, VOPP1View in SCUBA
EnterocytesMetallothionein metal response
Stress
BLVRB, MT1E, MT1F, MT1G, MT1H, MT1M, MT1X, TMEM176A +1 moreView in SCUBA
FibroblastsInflammatory ECM Remodeling
ECM remodeling
ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, NID2 +5 moreView in SCUBA
Glial cellsMetallothionein Stress Response
Stress
CADM3, CLU, CTNNAL1, IFI35, MT1E, MT1M, RARRES2, SERPINA5 +1 moreView in SCUBA
Mucosal-associated invariant T cellT cell Homeostasis
T cell maturation
APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R +19 more
Natural Killer cellsKIR+ NK Maturation
Immune regulation
AXIN1, ENC1, FAM53B, GTF3C1, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2 +3 moreView in SCUBA
PericytesQuiescent Pericyte State
Developmental
ARID5B, C1QTNF1, CPE, HOPX, ITGA7, LPP, MTHFD2, SLIT3 +1 moreView in SCUBA
Smooth muscle cellsGlucocorticoid Metallothionein Response
Stress
CEBPB, CEBPD, FKBP5, MT1E, MT1M, MT1X, PNRC1, TSC22D1 +3 moreView in SCUBA

About the gene

SynonymsMT2
Chromosome16: 56608584-56609497
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.