MT1E — Metallothionein 1E
MT1E belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MT1E's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | IFN-gamma Stress Response Inflammation | COX5B, FABP5, MT2A, PHPT1, PSMB9, PSME2, SUB1, VOPP1 | View in SCUBA |
| Enterocytes | Metallothionein metal response Stress | BLVRB, MT1F, MT1G, MT1H, MT1M, MT1X, MT2A, TMEM176A +1 more | View in SCUBA |
| Fibroblasts | Chemokine-secreting Fibroblasts Inflammatory | CA12, CCBE1, CHI3L2, CPXM2, CXCL13, CXCL5, GAS1, GPM6B +10 more | View in SCUBA |
| Glial cells | Metallothionein Stress Response Stress | CADM3, CLU, CTNNAL1, IFI35, MT1M, MT2A, RARRES2, SERPINA5 +1 more | View in SCUBA |
| Smooth muscle cells | Glucocorticoid Metallothionein Response Stress | CEBPB, CEBPD, FKBP5, MT1M, MT1X, MT2A, PNRC1, TSC22D1 +3 more | View in SCUBA |
About the gene
| Synonyms | MT1, MTD |
|---|---|
| Chromosome | 16: 56625475-56627112 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.