Integrated Stress Response
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 30 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and shows modest inflammation association (stronger in CD). Hub genes include CEBPB (C/EBP-beta, stress/inflammatory transcription factor), DDIT4 (REDD1, mTOR inhibitor under hypoxia/stress), IER3 (immediate early response, anti-apoptotic), MAFF (small Maf, stress-responsive bZIP), SLC16A3 (MCT4, lactate transporter, hypoxia/glycolysis), CLK1 (splicing kinase), PPP1R15A (GADD34, ER stress/ISR), PMAIP1 (NOXA, pro-apoptotic BH3-only), PLK3 (stress-activated kinase), ATF4 (ISR/ER stress transcription factor), NFKBIZ (IkB-zeta, NF-kB modulator), PTGER4 (prostaglandin E2 receptor), IFRD1 (transcriptional corepressor), CCNL1 (cyclin L1, splicing). The combination of ATF4, PPP1R15A (GADD34), DDIT4, PMAIP1, MAFF, CEBPB, IER3 is a hallmark of the integrated stress response (ISR) and hypoxia/metabolic stress. SLC16A3 (lactate export under hypoxia) and DDIT4 (mTOR inhibition under hypoxia) reinforce a hypoxia/metabolic stress theme. This module is distinct from M52 (canonical NF-kB/chemokine) and represents a stress-response program in inflamed colonocytes, likely driven by hypoxia and ER/metabolic stress. Neighbor M52 is the NF-kB inflammatory module; M51 represents the parallel stress/ISR arm activated in inflamed epithelium.
Genes
Most correlated modules
- NF-kB Inflammatory Response · correlation 0.81
- Epigenetic Remodeling Inflammation · correlation 0.78
- Transcriptional Golgi Remodeling · correlation 0.70
- Stress RNA Methylation · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.