Epigenetic Remodeling Inflammation
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 34 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and is strongly upregulated in both UC and CD inflammation (delta_inflammation=0.880, delta_inflammation_UC=0.887, delta_inflammation_CD=0.661). Hub genes include PRRC2C (RNA-binding), AFF4 (super elongation complex, transcription elongation), ARHGAP21 (Rho GAP, cytoskeletal), SETX (senataxin, RNA:DNA helicase/transcription termination), CHD7 (chromatin remodeler), BAZ2B (bromodomain, chromatin), AP3D1 (vesicle trafficking), SPEN (transcriptional repressor), KMT2C (histone H3K4 methyltransferase, MLL3), ZYX (zyxin, focal adhesion/actin), SPECC1 (cytoskeletal), ITSN2 (intersectin, endocytosis), RREB1 (transcription factor), CDC42BPB (MRCK-beta, actin cytoskeleton), KDM2A (histone demethylase), ARHGEF35 (Rho GEF), DIAPH2 (formin, actin), CEMIP2 (cell migration). The module is enriched in large chromatin-regulatory proteins (KMT2C, CHD7, BAZ2B, KDM2A, SPEN, AFF4, SETX) alongside cytoskeletal/actin regulators (ARHGAP21, ZYX, CDC42BPB, DIAPH2, SPECC1). The strong inflammation association and enrichment in inf_colono for several genes suggests this is an inflammation-associated program. The dominant theme is large chromatin remodeling/transcription elongation complexes co-expressed with cytoskeletal remodeling genes in inflamed colonocytes. The co-expression of chromatin regulators with actin/cytoskeletal genes may reflect a coordinated epithelial remodeling response to inflammation.
Genes
Most correlated modules
- Chromatin Regulatory Response · correlation 0.87
- TGF-β Chromatin Regulation · correlation 0.83
- Inflamed Barrier Remodeling · correlation 0.82
- Basement Membrane Remodeling · correlation 0.81
- Focal Adhesion Migration · correlation 0.80
- Integrated Stress Response · correlation 0.78
- Transcriptional Golgi Remodeling · correlation 0.75
- NF-kB Inflammatory Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.