NF-kB Inflammatory Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 36 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and is upregulated in inflammation (delta_inflammation=0.696), with many genes strongly enriched in inf_colono. The hub genes are a classic NF-kB/inflammatory response signature: ZC3H12A (MCPIP1/Regnase-1, mRNA decay of inflammatory transcripts), DUSP1 (MAPK phosphatase), FOSL1 (AP-1 transcription factor), NFKBIA (IkB-alpha, NF-kB inhibitor), ETS2 (ETS transcription factor), CXCL2, CXCL8, CXCL3 (inflammatory chemokines), ZFP36 (TTP, mRNA stability), REL (NF-kB subunit), BHLHE40 (transcription factor), PIM3 (kinase), STAT3, TNFAIP3 (A20, NF-kB negative regulator), LIF (cytokine), BCL3 (NF-kB coactivator), SOCS3 (JAK-STAT inhibitor), ATF3 (stress transcription factor), RASGEF1B. This is a canonical NF-kB/AP-1 inflammatory response module in colonocytes, featuring chemokines, NF-kB regulators, and immediate early response genes. The strong enrichment in inf_colono and the chemokine cluster (CXCL2/3/8) are definitive.
Genes
Most correlated modules
- Integrated Stress Response · correlation 0.81
- EGFR Wound Response · correlation 0.79
- Chromatin Regulatory Response · correlation 0.75
- Focal Adhesion Migration · correlation 0.74
- Epigenetic Remodeling Inflammation · correlation 0.73
- Inflammatory Stress Response · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.