Transcriptional Golgi Remodeling
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 38 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZBTB7A (transcriptional repressor of metabolic genes), ANKRD11 (chromatin/transcriptional coregulator), GTF2F1 (general transcription factor IIF), CPEB4 (RNA-binding translational regulator), DDX3X (RNA helicase, transcription/translation), MAML2 (Notch transcriptional coactivator). EXT1 (heparan sulfate biosynthesis), DHDDS (dolichol/glycosylation), GOLGA3 (Golgi organization), SLC35C1 (GDP-fucose transporter, glycosylation) suggest Golgi/glycosylation activity. ARHGEF5/11 are Rho GEFs. The module is inflammation-associated (delta_inflammation 0.629). The combination of transcriptional regulators and Golgi/glycosylation genes suggests a transcription-coupled glycosylation remodeling program in inflamed colonocytes.
Genes
Most correlated modules
- Membrane Cytoskeletal Remodeling · correlation 0.83
- Epigenetic Remodeling Inflammation · correlation 0.75
- Colonocyte Senescence · correlation 0.73
- Lipid Metabolism · correlation 0.70
- Integrated Stress Response · correlation 0.70
- P-TEFb Transcription Control · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.