NPNT — Nephronectin
NPNT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPNT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Dietary lipid absorption Absorption | ABCG5, ASAH2, BCO1, CD36, ENPP7, GATA4, LCT, LIN52 +3 more | View in SCUBA |
| Fibroblasts | BMP-Wnt Niche Signaling Developmental | CHMP4C, DCAF12L1, DIRAS1, DPEP2, GIPC3, ITGA9, LUZP2, MSTN +8 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, APOC1, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3 +8 more | View in SCUBA |
About the gene
| Synonyms | EGFL6L, POEM |
|---|---|
| Chromosome | 4: 105894775-106004027 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Cell adhesion, Differentiation |
Function
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.