RNA Decay Regulation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes ZNF143 (sequence-specific transcription factor, also involved in RNA Pol III regulation), HOXB6 (homeobox transcription factor), HELQ (DNA helicase, interstrand crosslink repair), DXO (decapping exoribonuclease, RNA quality control), TUT7 (terminal uridylyltransferase, RNA decay), DHX36 (RNA helicase, G-quadruplex resolution), ATG9B (autophagy membrane protein), KLHL28 (ubiquitin ligase adaptor), RNF139 (E3 ubiquitin ligase). The module combines RNA processing/decay (DXO, TUT7, DHX36) with transcription factors (ZNF143, HOXB6, ZNF14, ZNF451) and DNA repair (HELQ). The RNA decay enzymes are a coherent sub-theme. Mild inflammation trend without significance.
Genes
Most correlated modules
- Calcium-GPCR Signaling · correlation 0.85
- mTOR-Cytoskeletal Regulation · correlation 0.85
- Chromatin Epigenetic Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.