mTOR-Cytoskeletal Regulation
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include ARID4A (chromatin/transcription regulation), GPRASP1 (GPCR-associated sorting protein, receptor downregulation), MTCL1 (microtubule crosslinking), RRAGA (Rag GTPase A, mTORC1 amino acid sensing at lysosome), TMOD1 (tropomodulin, actin filament pointed-end capping), ANXA5 (annexin V, membrane binding), HAX1 (anti-apoptotic, mitochondria-ER), CHD7 (chromatin remodeler), MAGI2 (scaffold/PDZ protein). The module is heterogeneous with moderate coherence across many genes. RRAGA and GPRASP1 suggest receptor/nutrient signaling; TMOD1 and MTCL1 suggest cytoskeletal organization. The mild inflammation trend without significance and moderate remission reduction suggest a basal regulatory program.
Genes
Most correlated modules
- Cytoskeletal Remodeling · correlation 0.90
- Ubiquitin-Lysosomal Maintenance · correlation 0.88
- Calcium-GPCR Signaling · correlation 0.87
- RNA Decay Regulation · correlation 0.85
- Splicing & Transcription · correlation 0.83
- Chromatin Epigenetic Regulation · correlation 0.83
- Aminoacyl-tRNA Synthetase · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.