Calcium-GPCR Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub gene LCN10 is a lipocalin involved in lipid transport/binding. TRPC1 is a calcium channel involved in mechanosensing and store-operated calcium entry. RGS2 is a regulator of G-protein signaling known to modulate calcium and cAMP signaling and is induced by various stimuli. IMMP2L is a mitochondrial inner membrane peptidase. LMBRD1 is involved in cobalamin metabolism. The module is small (9 genes), low expression, with a significant decrease upon CD treatment. The genes are functionally heterogeneous, making a tight biological label difficult. The calcium/G-protein signaling axis (TRPC1, RGS2) is the most coherent sub-theme.
Genes
Most correlated modules
- Glucocorticoid Stress Response · correlation 0.95
- NF-κB Signaling · correlation 0.94
- Ubiquitin-Lysosomal Maintenance · correlation 0.92
- Mast Cell Identity · correlation 0.91
- Cytoskeletal Remodeling · correlation 0.90
- Epigenetic Transcriptional Control · correlation 0.90
- Transcriptional Metabolic Regulation · correlation 0.89
- Lysosomal Autophagy · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.