Type I Interferon
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 31 genes have a known function matching the annotation |
Why this annotation
This module contains the textbook canonical Type I interferon-stimulated gene (ISG) signature: IFIT1, IFIT2, IFIT3 (interferon-induced proteins with tetratricopeptide repeats), IFI6, IFI35, IFI44L (interferon-induced proteins), MX1, MX2 (dynamin-like GTPases, antiviral), OAS1, OAS3 (oligoadenylate synthetases, antiviral), RSAD2/viperin (antiviral), IFITM1 (interferon-induced transmembrane protein), GBP1 (guanylate binding protein), XAF1 (XIAP-associated factor, apoptosis/ISG), EPSTI1 (ISG), PLSCR1 (phospholipid scramblase, ISG), APOL4/APOL6 (innate immunity), SAMD9L (antiviral), PARP12 (antiviral). Strongly upregulated in UC inflammation and reversed in remission. This is the most coherent and canonical ISG module in the batch.
Genes
Most correlated modules
- Type I Interferon · correlation 0.86
- Type I Interferon Response · correlation 0.70
- Mitochondrial Maintenance · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.