Mitochondrial Maintenance
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include RUVBL1 (R2TP complex/chromatin remodeling), MRPS12 (mitochondrial ribosome), CISD3 (mitochondrial iron-sulfur cluster), SLC25A39 (mitochondrial metabolite carrier), MCUR1 (mitochondrial calcium uniporter regulator), and MITD1. Several genes reflect mitochondrial function and general housekeeping. CD33 and CTSC are mast cell markers but peripheral. The module is low-expression (0.254) with uniform distribution, consistent with a broadly expressed housekeeping/mitochondrial maintenance program rather than a specific mast cell state.
Genes
Most correlated modules
- Mast Cell Signaling · correlation 0.78
- Type I Interferon Response · correlation 0.73
- Actin Cytoskeletal Dynamics · correlation 0.66
- Immune Checkpoint State · correlation 0.63
- Cytoskeletal Signaling · correlation 0.62
- Type I Interferon · correlation 0.59
- Mast Cell Identity · correlation 0.58
- Actin Cytoskeleton Remodeling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.