Type I Interferon Response
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes: ST3GAL2 (sialyltransferase, glycosylation), CMPK2 (CMP kinase, interferon-stimulated gene), S1PR4 (sphingosine-1-phosphate receptor 4, immune cell trafficking), DDX60 (RNA helicase, antiviral/ISG), PSME2 (proteasome activator PA28β, IFN-γ induced), PSMB8 (immunoproteasome β5i, IFN-induced), PSMB2 (proteasome β2), PSMD13 (proteasome 26S), RTP4 (ISG, antiviral), DTX3L (ISG, PARP-dependent ubiquitin ligase), UNC93B1 (TLR trafficking, innate immunity), TRIM21 (ISG, antibody-mediated immunity), TP53I3 (p53-inducible, oxidative stress), HLA-DPB1 (MHC-II), ATOX1 (copper chaperone), GDF11 (TGF-β family). The strong enrichment of immunoproteasome subunits (PSMB8, PSME2), interferon-stimulated genes (CMPK2, DDX60, RTP4, DTX3L, TRIM21), and innate immune receptors (UNC93B1, S1PR4) clearly defines a type I/II interferon response with immunoproteasome induction. This is significantly upregulated in CD inflammation (delta_inflammation_CD = 0.322, sig.) and downregulated with treatment, consistent with IFN-driven inflammation. Neighbor M100 and M107 also have MHC-II genes, supporting an antigen presentation/interferon neighborhood.
Genes
Most correlated modules
- Mitochondrial Maintenance · correlation 0.73
- Type I Interferon · correlation 0.70
- Basal Mast Signaling · correlation 0.65
- Inflammasome Activation · correlation 0.65
- Actin Cytoskeletal Dynamics · correlation 0.62
- Centrosome Biogenesis · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.