Translation Initiation
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF3F, EIF3D, EIF3I (eukaryotic initiation factor 3 subunits), EIF4B, and PABPC1 (poly-A binding protein) — all core translation initiation machinery. NPM1 (nucleophosmin, ribosome biogenesis), PCBP2 (RNA-binding protein), and HADHA (mitochondrial fatty acid oxidation) are also present. LTA4H (leukotriene A4 hydrolase) is notable for mast cell eicosanoid biology. The module has high mean expression (1.421) and high pct positive (68.4%), consistent with broadly expressed housekeeping translation machinery. The disease correlations are essentially flat (all near zero), confirming a constitutive housekeeping program. The EIF3 complex dominance makes this a clear translation initiation module.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.84
- Mast Cell Activation · correlation 0.82
- Splicing & Transcription · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.