Splicing & Transcription
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes SRSF5 (serine/arginine-rich splicing factor 5), SF1 (splicing factor 1, branch point recognition), RAVER1 (splicing regulator), NSMCE3 (SMC5/6 complex, DNA repair), MED17 (Mediator complex subunit, transcription), GABARAPL1 (autophagy receptor), JMJD1C (histone H3K9 demethylase), AKIRIN2 (NF-κB/chromatin), VAMP2 (vesicle-associated membrane protein, exocytosis), TSPYL1 (nucleosome assembly). The module mixes RNA splicing (SRSF5, SF1, RAVER1), transcriptional regulation (MED17, JMJD1C, AKIRIN2), and autophagy (GABARAPL1). Strong decrease with UC remission. Neighbor M157 also has splicing factors, supporting a shared splicing/transcription neighborhood. The mixed nature reflects moderate coherence of the program.
Genes
Most correlated modules
- RNA Processing & Mitochondrial · correlation 0.87
- MARCH Ubiquitin Ligase · correlation 0.87
- Telomere Maintenance · correlation 0.84
- P-body mRNA Decay · correlation 0.83
- mTOR-Cytoskeletal Regulation · correlation 0.83
- Mitochondrial Respiratory Complex · correlation 0.82
- Protein Homeostasis · correlation 0.82
- Hypoxia Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.