Mast Cell Identity
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
This module has the highest mean expression (2.028) and detection rate (82.0%) in the batch, indicating a core constitutively expressed program. Hub genes include TPSAB1 (tryptase alpha/beta 1, the canonical mast cell serine protease and definitive mast cell marker), AHR (aryl hydrocarbon receptor, environmental sensor and mast cell regulator), ARHGDIB (Rho GDP dissociation inhibitor beta, expressed in hematopoietic cells), MAOB (monoamine oxidase B, expressed in mast cells), CD81 (tetraspanin, mast cell surface), CD44 (adhesion molecule), CD99 (cell surface glycoprotein), FXYD5 (ion transport regulator), CPA3 (carboxypeptidase A3, mast cell-specific protease), STK17B (serine/threonine kinase), DUSP6 (dual specificity phosphatase), DAD1 (defender against cell death), CIRBP (cold-inducible RNA binding protein). TPSAB1 and CPA3 are the two most canonical mast cell identity markers. AHR is a key transcriptional regulator in mast cells. MAOB, CD81, CD44, ARHGDIB are all well-documented in mast cells. This module clearly represents the core mast cell identity transcriptional program. The high expression and detection rate confirm this is a constitutive identity module.
Genes
Most correlated modules
- Ubiquitin-Lysosomal Maintenance · correlation 0.89
- Housekeeping Signaling · correlation 0.88
- Mast Cell Activation · correlation 0.86
- Translation Initiation · correlation 0.84
- Eicosanoid Biosynthesis · correlation 0.80
- Mitochondrial Protein Import · correlation 0.77
- Transcriptional Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.