Mast Cell Activation

Gene co-expression module in Mast cells

View this module in SCUBA

Why this annotation

This module contains a heterogeneous but functionally interpretable set of genes in mast cells. Hub genes include CCNG1 (cyclin G1, cell cycle/stress response), RACK1 (receptor for activated C kinase, signaling scaffold), CD37 (tetraspanin, immune cell surface), LETMD1 (mitochondria-associated), MRPL37 (mitochondrial ribosomal protein), IL18 (pro-inflammatory cytokine critical in mast cell activation), ALOX5AP (arachidonate 5-lipoxygenase-activating protein, eicosanoid synthesis), TNFSF12 (TWEAK, TNF superfamily cytokine), RENBP (renin-binding protein), HSD17B11 (hydroxysteroid dehydrogenase), SWAP70 (mast cell signaling, IgE receptor downstream), MFF (mitochondrial fission factor), CD7 (T/NK/mast cell surface marker), ACOT2 (acyl-CoA thioesterase, lipid metabolism), CTSF (cathepsin F, lysosomal protease). The co-occurrence of IL18, ALOX5AP, TNFSF12, SWAP70, and CD37 points toward a mast cell immune activation/cytokine secretion program. ALOX5AP is directly involved in leukotriene biosynthesis. The module is broadly expressed (54.9% positive, uniform across subsets) suggesting a constitutive or baseline activation state. The neighbor context (M93, M144, M80) includes mitochondrial and housekeeping programs, suggesting this module may represent a baseline mast cell functional identity program with inflammatory cytokine components. The strongest concordant signal is mast cell immune activation with cytokine/eicosanoid components.

Genes

Most correlated modules

• Mast Cell Identity · correlation 0.86
• Eicosanoid Biosynthesis · correlation 0.84
• Translation Initiation · correlation 0.82
• Vesicle Trafficking Secretion · correlation 0.81
• Mitochondrial Protein Import · correlation 0.76

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.