Autophagy & Lysosomal
Gene co-expression module in Mast cells
| Category | Degranulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 41 genes have a known function matching the annotation |
Why this annotation
The top hub gene ATG7 is the canonical E1-like enzyme essential for autophagosome formation, making autophagy the anchor program. AP3B1 (AP-3 beta subunit) mediates lysosomal biogenesis and vesicle trafficking. VPS13A and SNX1 are endosomal sorting factors. MADD/DENN is a Rab3-GEF involved in vesicle exocytosis. CRACR2A is a calcium sensor regulating vesicle trafficking. RPTOR (Raptor/mTORC1) is a master regulator of autophagy induction. DELE1 signals mitochondrial stress upstream of integrated stress response. MAP3K7/TAK1 is a stress-activated kinase that can induce autophagy. EXOC2 (exocyst) mediates vesicle tethering. The module is upregulated in CD inflammation (delta_inflammation_CD sig.), consistent with autophagy induction during intestinal inflammation. Neighbor M14 shares endolysosomal trafficking genes, supporting a related vesicular program.
Genes
Most correlated modules
- RNA Decay Processing · correlation 0.82
- Cytoskeletal Organization · correlation 0.79
- ER & Vesicle Trafficking · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.