Cytoskeletal Organization
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
No single dominant program. CNTROB (centrosome), KIF21B (kinesin/microtubule motor), MYO10 (myosin), CYFIP2 (WAVE/actin), TMEM30A (phospholipid flippase) suggest cytoskeletal and membrane organization. IFNAR2 and LGALS9 add interferon/immune regulation flavor. MAP2K2 (MEK2) and DEPDC5 (mTOR regulator) indicate signaling. ATP2B4 (PMCA4 calcium pump) links to calcium homeostasis. The module is heterogeneous but cytoskeletal/membrane organization is the plurality theme, consistent with neighbor modules M59 and M63.
Genes
Most correlated modules
- Endolysosomal Trafficking · correlation 0.86
- ER-Mitochondria Homeostasis · correlation 0.85
- Immune Activation Signaling · correlation 0.83
- General Cellular Maintenance · correlation 0.82
- ER & Vesicle Trafficking · correlation 0.82
- STAT6 IL-4 Signaling · correlation 0.81
- Histone Methylation Regulation · correlation 0.80
- Autophagy & Lysosomal · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.