ER & Vesicle Trafficking
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes point to two overlapping programs: ER protein processing (SEC63 — ER translocon component; EDEM3 — ER-associated degradation lectin; ABCB10 — mitochondrial/ER-associated transporter) and endolysosomal vesicle trafficking (VPS33A — HOPS complex for lysosomal fusion; DENND6A — DENN/Rab GEF; SCRN1 — secernin, vesicle exocytosis regulator). EFTUD2 is a core spliceosome component. ABI1 links to actin dynamics and endocytosis. SPN/CD43 is a leukocyte surface marker. CARS2 is a mitochondrial aminoacyl-tRNA synthetase. The module is significantly reduced by UC treatment (delta_treatment_UC sig.), suggesting it marks an active mast cell state suppressed by therapy. The ER quality control and vesicular trafficking themes are consistent with active secretory/degranulation-competent mast cells. Neighbor M28 shares the endolysosomal trafficking theme (VPS13A/SNX1 vs VPS33A/DENND6A), supporting a related but distinct vesicular program.
Genes
Most correlated modules
- General Cellular Maintenance · correlation 0.85
- RNA Decay Processing · correlation 0.85
- ER-Mitochondria Homeostasis · correlation 0.84
- Histone Methylation Regulation · correlation 0.84
- Cytoskeletal Organization · correlation 0.82
- SMC Chromatin Maintenance · correlation 0.81
- Integrin-Calcium Signaling · correlation 0.80
- Autophagy & Lysosomal · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.