RNA Decay Processing
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include SRSF1 (SR splicing factor), XRN1 (5'-3' RNA exonuclease), PARN (poly(A) RNA nuclease/deadenylase), SECISBP2 (selenocysteine insertion/RNA binding) — multiple RNA processing/decay factors. DMTF1 is a transcription factor linked to ARF/p53. CREBZF is a bZIP transcription factor. CENPC is a centromere protein. H2AC15 is a core histone. NIPBL loads cohesin. TRPM7 is a Mg2+/Zn2+ channel relevant to mast cells. E2F4 is a cell cycle TF. The module mixes RNA processing/decay with transcriptional regulation. The strongest coherent sub-theme is RNA processing/decay.
Genes
Most correlated modules
- Actin Cytoskeleton Organization · correlation 0.87
- Chromatin Cell Cycle · correlation 0.86
- ER & Vesicle Trafficking · correlation 0.85
- Histone Methylation Regulation · correlation 0.83
- Membrane Lipid Signaling · correlation 0.83
- SMC Chromatin Maintenance · correlation 0.83
- Autophagy & Lysosomal · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.