ER-Golgi Trafficking
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include RHOA (cytoskeletal Rho GTPase), MAP2K1 (MEK1/MAPK signaling), COPG1 and SEC24D (COPI/COPII vesicle coat proteins), ARL8B (lysosome/vesicle positioning), BCAP31 (ER membrane chaperone), ANXA6 (annexin membrane scaffold), YWHAG (14-3-3 signaling scaffold), TMEM109 (ER membrane). The module combines ER-Golgi vesicle trafficking machinery with cytoskeletal and MAPK signaling. Multiple weak/moderate memberships and moderate hub coherence suggest a mixed housekeeping program centered on intracellular trafficking and membrane dynamics. Uniform expression and high pct positive (47.9%) support a constitutive housekeeping role.
Genes
Most correlated modules
- Vesicle ER Trafficking · correlation 0.86
- Mitochondrial Metabolism Housekeeping · correlation 0.81
- Aminoacyl-tRNA Synthetases · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.