Mitochondrial Metabolism Housekeeping
Gene co-expression module in Mast cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include CSNK2B (casein kinase 2 beta, pleiotropic kinase), ATP5MC2 (ATP synthase subunit, OxPhos complex V), SNRPD2 (spliceosome snRNP), FDFT1 (squalene synthase, cholesterol biosynthesis), PMPCB (mitochondrial processing peptidase), SHMT2 (serine hydroxymethyltransferase, mitochondrial one-carbon metabolism), COX4I1 (cytochrome c oxidase subunit IV, complex IV), KDELR1 (ER retention receptor), and SYNGR2 (synaptogyrin, vesicle membrane). The module is mixed but has a notable mitochondrial/OxPhos component (ATP5MC2, PMPCB, SHMT2, COX4I1) alongside ER/Golgi (KDELR1, GNPTG, APH1A) and splicing (SNRPD2, EIF3K) genes. Flat disease correlations support a housekeeping metabolic program. Given the neighbor context (M197 UPR, M187 translation), this module likely represents general cellular metabolic housekeeping with mitochondrial emphasis.
Genes
Most correlated modules
- Cytoskeletal Remodeling · correlation 0.86
- Protein Homeostasis · correlation 0.84
- RNA Processing & Mitochondrial · correlation 0.83
- ER-Golgi Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.