Vesicle ER Trafficking
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
RAB6A (Golgi-to-ER retrograde trafficking), GDI1 (RAB GDP dissociation inhibitor, vesicle recycling), AUP1 (ER lipid droplet and ERAD), PTDSS1 (phosphatidylserine synthase, ER membrane lipid), TMBIM1 (lysosomal/ER membrane), and VAT1 (vesicle-associated) collectively define vesicular and ER membrane trafficking. GPI and EEF2 are metabolic/translational housekeeping genes. OXA1L links to mitochondrial membrane insertion. The dominant program is intracellular vesicle and ER membrane trafficking.
Genes
Most correlated modules
- RAS/Rho GTPase Signaling · correlation 0.92
- Mast Cell Homeostasis · correlation 0.92
- Mast Cell Specification · correlation 0.92
- Chromatin Remodeling · correlation 0.91
- PI3K Inflammatory Signaling · correlation 0.89
- STAT6 IL-4 Signaling · correlation 0.87
- Ubiquitin-Lysosomal Maintenance · correlation 0.87
- ER-Golgi Trafficking · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.