Histone Ubiquitination
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Top hub genes USP16 and WAC are both directly involved in histone ubiquitination: USP16 deubiquitinates H2A-K119ub1 (opposing Polycomb), and WAC promotes H2B ubiquitination via RNF20/40. MECP2 is a methyl-CpG binding chromatin regulator. GSE1 is a chromatin-associated protein in the CoREST complex. TOP1 (topoisomerase I) resolves torsional stress during transcription. AGO2 mediates RNA-directed chromatin silencing. CDK11B and E2F3 add cell-cycle-linked transcriptional regulation. This module is centered on histone ubiquitination and chromatin state regulation, complementing neighbor M199's broader chromatin/transcription theme.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.74
- p38-MK2 Stress Signaling · correlation 0.71
- Chromatin Epigenetic Regulation · correlation 0.65
- Chromatin Transcriptional Regulation · correlation 0.60
- Mast Cell Progenitor · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.