S-phase Histones
Gene co-expression module in Mast cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
The module is dominated by replication-dependent histone genes: H2AC16, H2AC11, H2AC12, H2AC25 (H2A variants), H3C4 (H3.1), H2BC12, H2BC7 (H2B variants), and H1-5 (linker histone). These are canonical S-phase histones synthesized during DNA replication. TIMELESS is a replication fork protection factor. This is a classic replication-coupled histone deposition signature marking S-phase cells. Peripheral genes (OSM, IL17RA, AIF1, PLA2G6, TRIB1) are weakly associated and likely represent co-varying immune signals or ambient RNA.
Genes
Most correlated modules
- Centrosome Biogenesis · correlation 0.81
- DNA Replication · correlation 0.80
- SWI/SNF Remodeling · correlation 0.75
- G2/M Checkpoint · correlation 0.75
- Mast Cell Progenitor · correlation 0.72
- Mitotic Spindle · correlation 0.69
- DNA Damage Response · correlation 0.69
- Transcriptional Regulation · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.