Tryptase Expression Mixed
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 23 genes have a known function matching the annotation |
Why this annotation
This module has very low expression (15.8% positive) and unknown coherence, suggesting a poorly defined or sparse program. TPSD1 (tryptase delta) is a mast cell-specific serine protease stored in secretory granules, directly relevant to mast cell identity. WDR35 is an IFT complex component (cilia). SIK1 is a salt-inducible kinase involved in inflammatory gene regulation. TRDMT1 is a DNA methyltransferase. USP11 and OTUD5 are deubiquitinases. U2AF1 is a splicing factor. NBPF26 is a copy-number variable gene. CACNA1H is a T-type calcium channel. PROM1 (CD133) marks progenitors. The module is heterogeneous; TPSD1 is the only clear mast cell marker but the rest are diverse. The low expression and heterogeneity suggest a weakly defined mixed module with a mast cell tryptase component.
Genes
Most correlated modules
- ER Protein Quality Control · correlation 0.90
- Innate Immune Stress · correlation 0.89
- Endosomal Autophagy Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.