Endosomal Autophagy Trafficking
Gene co-expression module in Mast cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include CLEC16A (autophagy regulator controlling MHC-II antigen presentation and mitophagy), VPS37B (ESCRT-I complex, endosomal sorting), HOOK2 (endosome-cytoskeleton linker), MYO1E (actin-based motor for endosomal trafficking), DCTN4 (dynactin, vesicle transport), NEDD9 (scaffold for endosomal/adhesion signaling), LIMK2 (actin dynamics). CLEC16A is a particularly strong anchor — it is a well-established regulator of autophagy and lysosomal biogenesis in immune cells including mast cells. The module collectively points to endosomal sorting and autophagy-related vesicle trafficking. CCL4L2 is a chemokine but may be a peripheral member. Neighbor M188 covers general RNA/protein homeostasis, while this module is more specifically endosomal/autophagic.
Genes
Most correlated modules
- NFAT Mast Cell Activation · correlation 0.87
- NF-κB Immediate Response · correlation 0.87
- LXR/PPAR Repression · correlation 0.86
- Innate Immune Stress · correlation 0.86
- ER Protein Quality Control · correlation 0.86
- RNA & Protein Homeostasis · correlation 0.82
- DNA Damage Response · correlation 0.81
- Tryptase Expression Mixed · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.