Innate Immune Stress
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include SUPT6H (transcription elongation), XPC (nucleotide excision repair), TBK1 (innate immune kinase activating IRF3/NF-kB), MAPK8/JNK (stress-activated kinase), BABAM2 (DNA damage response), SENP5 (SUMO protease regulating stress responses), and SP4 (transcription factor). The module shows the strongest UC inflammation correlation (0.799) of this batch, suggesting an active inflammatory/stress signaling program. TBK1 is a central innate immune kinase; MAPK8 mediates inflammatory and apoptotic stress signaling. The combination of DNA damage sensing (XPC, BABAM2), transcriptional stress response (SUPT6H), and innate immune kinase signaling (TBK1, MAPK8) points to an integrated inflammatory stress response program upregulated in IBD.
Genes
Most correlated modules
- NF-κB Stress Signaling · correlation 0.92
- ER Protein Quality Control · correlation 0.92
- Circadian Transcription · correlation 0.90
- Tryptase Expression Mixed · correlation 0.89
- LXR/PPAR Repression · correlation 0.89
- Mitochondrial Fusion Stress · correlation 0.89
- Inflammatory IRAK3-BATF Response · correlation 0.89
- Ubiquitin-Chromatin Regulation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.